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Regulatory T Cell Frequencies and Phenotypes Following Anti-Viral Vaccination. Charlotte de Wolf, Susan van Aalst, Irene Ludwig, Caroline L. Bodinham, David J. Lewis,  Ruurd van der Zee, Willem van Eden, Femke Broere. Accepetd for publication

Bystander activation of irrelevant CD4+ T cells following antigen-specific vaccination occurs in the presence and absence of adjuvant. van Aalst S, Ludwig IS, van der Zee R, van Eden W, Broere F. PLoS One. 2017 May 10;12(5):e0177365. doi: 10.1371/journal.pone.0177365. eCollection 2017.

Inflammatory responses to influenza vaccination at the extremes of age. McDonald JU, Zhong Z, Groves HT, Tregoning JS. Immunology. 2017 Apr 4. doi: 10.1111/imm.12742

Dynamics of APC recruitment at the site of injection following injection of vaccine adjuvants. van Aalst S, Ludwig IS, van Kooten PJ, van der Zee R, van Eden W, Broere F. Vaccine 2017 Mar 14;35(12):1622-1629. doi: 10.1016/j.vaccine.2017.02.005. Epub 2017 Feb 17.

Muffins: multi-formalism interaction network simulator. Huihai Wu, Axel von Kamp, Vytautas Leoncikas, Wataru Mori, Nilgun Sahin, Albert Gevorgyan, Catherine Linley, Marek Grabowski, Ahmad A Mannan, Nicholas Stoy, Graham R Stewart, Lara T Ward, David JM Lewis, Jacek Sroka, Hiroshi Matsuno, Steffen Klamt, Hans V Westerhoff, Johnjoe McFadden, Nicholas J Plant and Andrzej M Kierze. npj  Systems  Biology  and  Applications (2016) 2, 16032; doi:10.1038/npjsba.2016.32; published online 17 November 2016.

A blood RNA signature for tuberculosis disease risk: a prospective cohort study. Zak D.E., Penn-Nicholson A., Scriba T.J., Thompson E., Suliman S., Amon L.M., Mahomed H., Erasmus M., Whatney W., Hussey G.D., Abrahams D., Kafaar F., Hawkridge T., Verver S., Hughes E.J., Ota M., Sutherland J., Howe R., Dockrell H.M., Boom W.H., Thiel B., Ottenhoff T.H., Mayanja-Kizza H., Crampin A.C., Downing K., Hatherill M., Valvo J., Shankar S., Parida S.K., Kaufmann S.H., Walzl G., Aderem A., Hanekom W.A.; ACS and GC6-74 cohort study groups. The Lancet. 2016 Jun 4;387(10035):2312-22. doi: 10.1016/S0140-6736(15)01316-1.

A Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus Disease Respiratory Syncytial Virus Disease McDonald J.U., Kaforou M., Clare S., Hale C., Ivanova M., Huntley D., Dorner M., Wright V.J., Levin M., Martinon-Torres F., Herberg J.A., Tregoning J.S. mSystems 2016 Jun; 1(3):e00051-16. doi:10.1128/mSystems.00051-16

Development of a custom pentaplex sandwich immunoassay using Protein-G coupled beads for the Luminex xMAP platform McDonald J.U., Ekeruche-Makinde J., Ho M.M., Tregoning J.S., Ashiru O.   J Immunol Methods. 2016 Jun;433:6-16. doi: 10.1016/j.jim.2016.02.018

Use of the Microparticle Nanoscale Silicon Dioxide as an Adjuvant To Boost Vaccine Immune Responses against Influenza Virus in Neonatal Mice . Russell R.F., McDonald J.U., Lambert L., Tregoning J.S. J. Virol. May 2016; 90:4735– 4744. doi:10.1128/JVI.03159-15.

SLE-key rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus: Developing the ImmunArray iCHIP.  Putterman C., Wu A.,  Reiner-Benaim A., Batty DS Jr ,  Sanz I., Oates J.,  Jakobi K., Petri M. , Safer P.,  Gerwien R., Sorek R., Blumenstein Y., Cohen I.R. J Immunol Methods. 2016 Feb; 429:1-6. doi: 10.1016/j.jim.2015.12.003.

Early Rise of Blood T Follicular Helper Cell Subsets and Baseline Immunity as Predictors of Persisting Late Functional Antibody Responses to Vaccination in Humans  Spensieri F., Siena E., Borgogni E., Zedda L., Cantisani R., Chiappini N., Schiavetti F., Rosa D., Castellino F., Montomoli E., Bodinham C.L., Lewis D.J., Medini D., Bertholet S., Del Giudice G.  Plos ONE, 2016  11(6):e0157066. doi: 10.1371/journal.pone.0157066

Reprogramming the T cell response to tuberculosis Woodworth J.S. and Andersen P. Trends Immunol., 2016    37(2):81-3. doi: 10.1016/

Expanded metabolite coverage of Saccharomyces cerevisiae extract through improved chloroform/methanol extraction and tert-butyldimethylsilyl derivatization. Khoomrung S., Martinez J.L., Tippmann S., Jansa-Ard S., Buffing M.F., Nicastro R., Nielsen J. Analytical Chemistry Research 6 (2015) 9-16 DOI: 10.1016/j.ancr.2015.10.001

Interferon-gamma from brain leukocytes enhances meningitis by Type 4 Streptococcus pneumoniae Pettini E., Fiorino F., Cuppone A.M., Iannelli F., Medaglini D., Pozzi G.  Frontiers of Microbiology, 2015  doi: 10.3389/fmicb.2015.01340

Epigenetics and proteomics join transcriptomics in the quest for tuberculosis biomarkers  Esterhuyse M.M., Weiner J. 3rd, Caron E., Loxton A.G., Iannaccone M., Wagman C., Saikali P., Stanley K., Wolski W.E., Mollenkopf H.J., Schick M., Aebersold R., Linhart H., Walzl G., Kaufmann S.H. MBio., 2015   6(5):e01187-15. doi: 10.1128/mBio.01187-15.

Partial attenuation of RSV with a deletion of the SH gene is associated with elevated IL-1B Russell R.F., McDonald J.U., Ivanova M., Zhong Z., Bukreyev A., Tregoning J.S   Journal of Virology, 2015   89(17):8974-81. doi: 10.1128/JVI.01070-15                                                           

Evaluating the efficiency of isotope transmission for improved panel design and a comparison of the detection sensitivities of mass cytometer instruments Tricot S., Meyrand M., Sammicheli C., Elhmouzi-Younes J., Corneau A., Bertholet S., Malissen M., Le Grand R., Nuti S., Luche H., Cosma A  Cytometry A., 2015   87(4):357-68. doi: 10.1002/cyto.a.22648

The human immune response to tuberculosis and its treatment: a view from the blood  Cliff J.M., Kaufmann S.H.E., McShane H, van Helden P., O’Garra A Immunological Reviews, 2015 264 (1): 88-102.doi:10.1111/imr.12269                            

Vaccines, new opportunities for a new society  Rappuoli R., Pizza M., Del Giudice G., De Gregorio E.  Proc Natl Acad Sci U S A., 2014 111(34):12288-93. doi: 10.1073/pnas.140298111

Toward a unified biosignature for tuberculosis Maertzdorf J., Kaufmann S.H., Weiner J. 3rd.  Cold Spring Harb Perspect Med., 2014   pii: a018531. doi: 10.1101/cshperspect.a018531

Novel vaccination strategies against tuberculosisAndersen P. and Kaufmann S.H.E.  Cold Spring Harbor Laboratory Press, 2014   doi:10.1101/cshperspect.a018523.4(6): a018523

Challenges and responses in human vaccine development  Kaufmann S.H.E , Mc Elrath M.J., Lewis D.J.M., Del Giudice G.   Curr. Opin. Immunol, 2014 doi:10.1016/j.coi.2014.01.009

Reverse translation in tuberculosis: neutrophils provide clues for understanding development of active disease  Dorhoi A., Iannaccone M., Maertzdorf J., Nouailles G., Weiner  J. 3rd,  Kaufmann S.H.E.  Frontiers in Immunol.,  2014 doi:10.3389/fimmu.2014.00036

Tuberculosis vaccine development at a divide  Kaufmann S.H.E.  Curr Opin Pulm Med.,  2014  20(3):294-300. doi: 10.1097/MCP.0000000000000041

Progress in tuberculosis vaccine development and host-directed therapies—a state of the art review  Kaufmann, S.H.E., Lange C., Rao M., Balaji K.N., Lotze M., Schito M., Zumla A.I., Maeurer M. Lancet Respir Med., 2014  2(4):301-20. doi: 10.1016/S2213-2600(14)70033-5

Recent advances towards tuberculosis control: vaccines and Biomarkers  Weiner J. 3rd & Kaufmann  S.H.E.  J Intern Med,  2014   275(5):467-80. doi: 10.1111/joim.12212

TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: ‘How can big data help?’  Dutruel C., Thole J., Geels M., Mollenkopf H.J., Ottenhoff T., Guzman C.A., Fletcher H.A., Leroy O., Kaufmann S.H. Vaccine,  2014  32(35):4365-8. doi: 10.1016/j.vaccine.2014.06.014

Standardization and simplification of vaccination records Maurer W., Seeber L., Rundblad G., Kochhar S., Trusko B., Kisler B., Kush R., Rath B.  Vienna Vaccine Safety Initiative Expert Review of Vaccines, 2014  13(4):545-59. doi: 10.1586/14760584.2014.892833

The dual role of biomarkers for understanding basic principles and devising novel intervention strategies in tuberculosis Weiner J. 3rd, Maertzdorf J., Kaufmann S.H.   Ann N Y Acad Sci., 2013  1283:22-9. doi: 10.1111/j.1749-6632.2012.06802.x

OMIP-016: Characterization of antigen-responsive macaque and human T –cells  Guenounou S., Bosquet N., Dembek C.J., Le Grand R., Cosma A.  Cytometry PART A,  2013   83(2):182-4. doi: 10.1002/cyto.a.22233

Tuberculosis vaccines: time to think about the next generation Kaufmann S.H.E.  Seminars in Immunology, 2013 25: 172-181. doi:10.1016/j.smim.2013.04.006

Defining the range of pathogens susceptible to ifitm3 restriction using a knockout mouse model Everitt A. R., Clare S., McDonald J. U., Kane L., Harcourt K., Ahras M., Lall A., Hale C., Rodgers A., Young D. B., Haque A., Billker O., Tregoning J. S., Dougan G., Kellam P.  Plos one,  2013   8(11):e80723. doi: 10.1371/journal.pone.0080723

Inflammation in tuberculosis: interactions, imbalances and interventions (Special issue: Host pathogens) Kaufmann S.H.E. and  Dorhoi A. Curr. Opin. Immunol., 2013   25: 441–449. doi:10.1016/j.coi.2013.05.005                                                                                                        

Enabling biomarkers for tuberculosis control Maertzdorf J., Weiner J. 3rd, Kaufmann S.H.  Int J Tuberc Lung Dis., 2012   16(9):1140-8. doi: 10.5588/ijtld.12.0246.                        

Tuberculosis vaccine development: strength lies in tenacity  Kaufmann S.H.E.  Trends in Immunol., 2012   33(7):373-9. doi: 10.1016/